Cell Free DNA Genetic Testing is Changing Chicago Obstetrics and Gynecology Practices
Northwestern Women’s Health Associates, S.C
680 N. Lake Shore Drive #1200, Chicago, 60611 | Get Directions

Cell Free DNA Genetic Testing is Changing Chicago Obstetrics and Gynecology Practices

Dr. Stanley Friedell, Northwestern Women's Health Associates S.C Providing Call Free DNA testing

Each of us have 2 sets of 23 chromosomes for a total of 46 chromosomes. During a pregnancy your Chicago OBGYN may offer genetic testing that screens for aneuploidy. Aneuploidy is any deviation from the standard set of chromosomes. If aneuploidy is detected it could mean that there is a presence of more or less chromosomes.

Traditional tests for aneuploidy include CVS and amniocentesis. These tests can provide a lot of information but they also offer some risk of miscarriage. Recent improvements in technology have introduced cell free DNA testing which has no risk of miscarriage and can be done as early as 10 1/2 weeks gestation. Cell free DNA test accuracy is 99% for the three most common abnormalities and not for all chromosomes however, these non-invasive tests are not the first choice for all patients. It is the opinion of ACOG that cell free DNA screening is appropriate under the following conditions:

  • Women over the age of 35
  • Women with fetal ultrasonography findings that are concerning for aneuploidy
  • Women who had aneuploidy in a prior pregnancy
  • Women with abnormal first- or second-trimester genetic screening tests
  • Parents with a balanced translocation and an increased risk of Trisomy 21 or 13.

Negative results are not diagnostic, and all positive results should be confirmed with invasive testing (chorionic villus sampling [CVS] or amniocentesis).

ACOG does not currently recommend the routine use of cell-free fetal DNA without a comprehensive history and adequate patient counseling, as well as a designation of “high risk.”

Many patients wonder why this test isn’t being performed on women who are not considered high risk when cell free DNA test accuracy is so convincing. There is a risk associated with false positives:

There is some preliminary data about the source of false-positive results; potential causes include an inadequate fetal fraction of cell-free DNA, maternal or placental mosaicism, and a vanishing twin.

It has been proposed by Mennuti and colleagues, that a registry of false-positive and false-negative results be established in an effort to gather further data. It is also anticipated that as low-risk patients and aneuploidies of lower and lower prevalence are incorporated into noninvasive testing, the false-positive rate will rise. Their findings have implications for patient counseling, patient distress, invasive testing, and reimbursement.

Your Chicago obstetrics and gynecology provider will work with you to determine what genetic testing is necessary during your pregnancy. Invasive testing is not done until a potential risk for aneuploidy has been determined. If you have any questions about cell free DNA test accuracy, it’s best to see your obstetrician in Chicago,. At Northwestern Women’s Health Associates  we treat every patient and every pregnancy individually. You will be given the time and consideration needed to make the necessary decisions surrounding genetic testing during pregnancy.

We are accepting new patients! To schedule an appointment with Northwestern Women’s Health Associates , call us at 312-440-9400 or request an appointment right on our website.

DISCLAIMER: All information on this website is provided for informational purposes only and is not intended to be construed as medical advice. Northwestern Women’s Health Associates shall not be liable for any errors or inaccuracies contained herein, or any actions taken in reliance thereon.

 

Back to Home Page

Comments are closed.


Appointment Request

  • Northwestern Women's Health Associates
    5 Dr. Stanley Friedell, 5 Star Review By Gerilynn H.


    Dr. Regina Belmonte has been providing all the services I have needed for over 12 years. She saw me through both of my pregnancies and her expertise is vast. Even after I moved far away from the city, I still embrace and look forward to her care and services, and I refuse to switch doctors. She is worth the trip! Going through both pregnancies I had to meet with all of the Dr's. and all were wonderful. The nurses are fantastic. I have gotten 98% of what I have ever needed just talking to a nurse. So grateful for this practice and so confident with the care I receive.
  • Northwestern Women's Health Associates
    5 Dr. Stanley Friedell, 5 Star Review By Jelly T.


    Dr. Abbie Roth is GOLD!
    I have never met a doctor who is caring and brilliant and with a great sense of humor as doctor Abbie Roth. She is very professional and has an excellent bedside manner. When I had a life threatening complication after my C-section, she and her Prentice team of doctors and nurses were such an efficient team under pressure while making sure they explain every process and steps during the situation. Dr. Abbie Roth and her team literally saved my life! I am very fortunate to have met Dr. Roth, I will never forget her and will continue to see her for my future OB/Gyne health. I highly recommend this practice and Dr. Roth!
  • Northwestern Women's Health Associates
    5 Dr. Stanley Friedell, 5 Star Review By Jessica


    If you are new to Chicago or are just looking for a new physician, please make an appointment with Dr. Friedell. This is the first time in my adult life, that a doctor spent an hour with me going over my medical history, asking questions and documenting my history accurately. His assessment and subsequent surgery were all done t a T! I wouldn't hesitate to recommend him or his staff. I have had very positive experiences every time I've gone and I always leave feeling like I've been really seen and heard.
  • Northwestern Women's Health Associates
    5 Dr. Stanley Friedell, 5 Star Review By Monica E.


    I was recommended to NWWH through a friend after a year of unsuccessful IUI with my partner. We were seen and cared for by Dr. Friedell. Best decision ever. You will definitely wait for the doctor for maybe 30 minutes past your appointment time but you will not regret it. His thoroughness and patience to explain everything to us in a way we understood was amazing. He was quick to start a game plan for us. We will definitely stick with Dr. Friedell as our OB/GYN.

    Apart from Dr. Friedell, the staff was quick to perform any lab work and ultrasounds with friendly conversation and compassion. This type of service really helps when we've gone through a rough time trying to get pregnant. Definitely make an appointment with Dr. Friedell.
  • Northwestern Women's Health Associates
    5 Dr. Stanley Friedell, 5 Star Review By Jennifer H.


    I have been going to Dr. Friedell for over a year now and he has been nothing less than amazing. When I first came to him to discuss pregnancy, he was incredibly informative and understanding. He was also willing to take the time to answer all of my questions and help in any way he could. He just delivered my son in March and to say he went the extra mile during delivery would be an understatement. I had some complications and with any other doctor I would have had a c-section. Dr. Friedell worked with me and was extremely patient and because of his care and expertise I had a successful vaginal delivery. I cannot recommend him highly enough!
  • Northwestern Women's Health Associates
    5 Dr. Stanley Friedell, 5 Star Review By Karima R.


    I have been going to this office for little over a month now due to some complications! I have been seen Dr. Friedell, he is very caring and always made sure he answers all my concerns. I am beyond impressed with my experience with Dr Friedell and his PA " Amber". Dr Friedell called me many times after hours to talk to me about my medical results and answers any concerns that I have.

    I would highly recommend Dr Friedell.
  • Northwestern Women's Health Associates
    5 Dr. Stanley Friedell, 5 Star Review By Elizabeth T.


    I have been a patient of this practice for over 5 years now and have only positive reviews of Dr. Feldstein. He was the doctor on call and delivered my third son without any complications. He was knowledgeable, patient focused and went above and beyond to answer my questions and provide a safe and healthy delivery. I also want to note his positive bedside manner to not only my husband and I, but to the nursing staff that was working with him. He was very respectful and I am very thankful to have had him for my delivery. I would recommend this group, Dr. Feldstein in particular without reservation.
  • Northwestern Women's Health Associates
    5 Dr. Stanley Friedell, 5 Star Review By LA


    I switched to Dr. Roth mid pregnancy due to health insurance reasons and it was probably the best decision I have ever made in my life. She is definitely warm and funny but also extremely competent and knowledgeable. I would say what makes her stand out from other doctors is how calm and not reactive she is in even the most dire situations. My son was in serious fetal distress (unexpected and not preventable) and she was very calm and reassuring as we literally ran to the OR for my c section. With the rise of c sections today I feel Dr. Roth is one of the few remaining fabulous ob's that truly plans for normal vaginal births (your choice if you want an epi or not) and although I needed a c section I knew it was truly necessary. I could not speak more highly of her, not only did she save my sons life but she made me feel safe, secure and empowered even when decisions and actions were out of my hands.
  • Northwestern Women's Health Associates
    5 Dr. Stanley Friedell, 5 Star Review By Dana M.


    I love Dr. Belmonte. I have been going to her since 2006! She rocks!!! She is straight to the point, I love that about her. When I leave her office after seeing her I always feel great, like a just left a good friends house or something!
  • Northwestern Women's Health Associates
    5 Dr. Stanley Friedell, 5 Star Review By Barbara A


    I can not tell you how wonderful my experiences have been. Dr. Sharon Wise is my doctor and she is fantastic. She is straightforward and honest about treatments and procedures. I enjoy her sense of humor, and I found her bedside manner when delivering my son to be excellent.